Anorexia nervosa (AN) is an eating disorder observed predominantly in women and girls
that is characterized by a low body-mass index, hypophagia, and hyperactivity. Activity …

Background The dopamine D 2 receptor (D 2 R) has received much attention in obesity
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

We found that development of obesity was coupled with emergence of a progressively
worsening deficit in neural reward responses. Similar changes in reward homeostasis …

Reports an error in" Dopamine D2 receptors in addiction-like reward dysfunction and
compulsive eating in obese rats" by Paul M. Johnson and Paul J. Kenny (Nature …

Activity-based anorexia (ABA) is considered an animal model for anorexia nervosa (AN). By
scheduled feeding and voluntary wheel running, it mimics severe body weight loss and …

We found that development of obesity was coupled with the emergence of a progressively
worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine …

Anorexia nervosa (AN) is an eating disorder characterized by severe hypophagia and
weight loss, and an intense fear of weight gain. Activity-based anorexia (ABA) refers to the …

The nucleus accumbens (NAcc) mediates feeding reward; its activity reflects tastants'
hedonic value. NAcc dopamine guides immediate responses to reward, however, its …

While weight gain is clearly promoted by excessive energy intake and reduced expenditure,
the underlying neural mechanisms of energy balance remain unclear. The nucleus …