ATM activity contributes to the tumor-suppressing functions of p14ARF
Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …
signals. The biochemical basis of this has not been fully elucidated. We report here that …
[HTML][HTML] p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner
While p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the
mechanism by which p14ARF inhibits tumorigenesis independently of p53 remains elusive …
mechanism by which p14ARF inhibits tumorigenesis independently of p53 remains elusive …
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis
L Moore, S Venkatachalam, H Vogel, JC Watt, CL Wu… - Oncogene, 2003 - nature.com
The p19 ARF gene product responds to oncogenic stresses by interfering with the inhibitory
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …
p19ARF is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
D Tolbert, X Lu, C Yin, M Tantama… - Molecular and cellular …, 2002 - Am Soc Microbiol
Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …
oncogenic stress by regulating the activity of p53. This response is mediated by …
Multiple domains of the mouse p19ARF tumor suppressor are involved in p53-independent apoptosis
M Matsuoka, M Kurita, H Sudo, K Mizumoto… - Biochemical and …, 2003 - Elsevier
The ARF (p19ARF for the mouse ARF consisting of 169 amino acids and p14ARF for the
human ARF consisting of 132 amino acids) genes upregulate p53 activities to induce cell …
human ARF consisting of 132 amino acids) genes upregulate p53 activities to induce cell …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism
H Rizos, LL Scurr, M Irvine, NJ Alling, RF Kefford - Cell Cycle, 2007 - Taylor & Francis
Alterations in the ARF tumour suppressor protein (also known as p14ARF in humans and
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …