Four-factor prothrombin complex concentrate in adjunct to whole blood in trauma-related hemorrhage: Does whole blood replace the need for factors?
BACKGROUND The use of whole blood (WB) for the treatment of hemorrhagic shock and
coagulopathy is increasing in civilian trauma patients. Four-factor prothrombin complex …
coagulopathy is increasing in civilian trauma patients. Four-factor prothrombin complex …
Four-factor prothrombin complex concentrate is associated with improved survival in trauma-related hemorrhage: a nationwide propensity-matched analysis
METHODS Two-year (2015–2016) analysis of the American College of Surgeons-Trauma
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …
Four-factor prothrombin complex concentrate: an indispensable adjunct in coagulopathy of trauma management–a comparative review of the literature over 2 decades
M Osama, SH Syed, HMSA Nasir… - European Surgical …, 2020 - karger.com
Background: Damage control resuscitation forms the cornerstone of management in trauma
surgery. Several blood products have been widely used for preoperative transfusions prior …
surgery. Several blood products have been widely used for preoperative transfusions prior …
Utility of 4-factor prothrombin complex concentrate in trauma and acute-care surgical patients
W Sellers, C Bendas, F Toy, B Klock… - Journal of Osteopathic …, 2018 - degruyter.com
Context Since 2013, prothrombin complex concentrate (PCCs) have been approved in the
United States for the reversal of anticoagulation induced by vitamin K antagonists. However …
United States for the reversal of anticoagulation induced by vitamin K antagonists. However …
The role of four-factor prothrombin complex concentrate in coagulopathy of trauma: a propensity matched analysis
BACKGROUND Coagulopathy is a common complication after severe trauma. The efficacy
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …
Efficacy and safety of early administration of 4-factor prothrombin complex concentrate in patients with trauma at risk of massive transfusion: the PROCOAG …
P Bouzat, J Charbit, PS Abback, D Huet-Garrigue… - Jama, 2023 - jamanetwork.com
Importance Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …
Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a …
P Bouzat, JL Bosson, JS David, B Riou, J Duranteau… - Trials, 2021 - Springer
Background Optimal management of severe trauma patients with active hemorrhage relies
on adequate initial resuscitation. Early administration of coagulation factors improves post …
on adequate initial resuscitation. Early administration of coagulation factors improves post …
Three-versus four-factor prothrombin complex concentrates for “factor-based” resuscitation in a porcine hemorrhagic shock model
DM Moe, MS Lallemand, JM McClellan… - Journal of Trauma …, 2017 - journals.lww.com
BACKGROUND Bleeding is a leading cause of preventable death after severe injury.
Prothrombin complex concentrates (PCC) treat inborn coagulation disorders and reverse …
Prothrombin complex concentrates (PCC) treat inborn coagulation disorders and reverse …
Potential use of prothrombin complex concentrate in trauma resuscitation
N McSwain Jr, J Barbeau - Journal of Trauma and Acute Care …, 2011 - journals.lww.com
Hemorrhage control depends on the availability of the 13 factors in the coagulation cascade
plus the definitive extrinsic Factor XIV: clamps and ligatures. Factor XIV depends on delivery …
plus the definitive extrinsic Factor XIV: clamps and ligatures. Factor XIV depends on delivery …
Less is more: low-dose prothrombin complex concentrate effective in acute care surgery patients
JA Quick, JM Meyer, JP Coughenour… - The American …, 2015 - journals.sagepub.com
Optimal dosing of prothrombin complex concentrate (PCC) has yet to be defined and varies
widely due to concerns of efficacy and thrombosis. We hypothesized a dose of 15 IU/kg …
widely due to concerns of efficacy and thrombosis. We hypothesized a dose of 15 IU/kg …