Background & aims: Corticotropin Releasing Hormone (CRH) is the major mediator of the
adaptive response to stressors in mammals. Studies from several groups including ours …

Psychological stress alters the gut microbiota and predisposes individuals to increased risk
for enteric infections and chronic bowel conditions. Intestinal epithelial cells (IECs) are …

Psychological stress alters the gut microbiota and predisposes individuals to increased risk
for enteric infections and chronic bowel conditions. Intestinal epithelial cells (IECs) are …

BACKGROUND & AIMS:: Defects in the colonic innate immune response have been
associated with inflammatory bowel disease (IBD). Corticotropin-releasing hormone (CRH …

Psychological stress can lead to gut dysbiosis, yet the precise mechanisms underlying the
transfer of stress signals from the brain to the gut remain elusive. Here we describe a new …

Psychosocial stress is a vital factor contributing to the pathogenesis and progression of
inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to …

In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier
contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety …

A recent study by Wei, Liu, Hou et al the investigated how psychological stress conveys
epithelial disturbance. Using chronic restraint stress (CRS) to model psychological stress in …

The corticotropin-releasing hormone family mediates functional responses in many organs,
including the intestine. Activation of corticotropin-releasing hormone receptor 2 (CRHR2) in …

Converging evidence supports the involvement of pro-inflammatory pathways and the gut
microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest …