Pervasive sharing of genetic effects in autoimmune disease
Genome-wide association (GWA) studies have identified numerous, replicable, genetic
associations between common single nucleotide polymorphisms (SNPs) and risk of …
associations between common single nucleotide polymorphisms (SNPs) and risk of …
Autoimmune diseases: insights from genome-wide association studies
Autoimmune diseases occur when an individual's own immune system attacks and destroys
his or her healthy cells and tissues. Although it is clear that environmental stimuli can …
his or her healthy cells and tissues. Although it is clear that environmental stimuli can …
Autoimmune disease classification by inverse association with SNP alleles
M Sirota, MA Schaub, S Batzoglou, WH Robinson… - PLoS …, 2009 - journals.plos.org
With multiple genome-wide association studies (GWAS) performed across autoimmune
diseases, there is a great opportunity to study the homogeneity of genetic architectures …
diseases, there is a great opportunity to study the homogeneity of genetic architectures …
Detecting shared pathogenesis from the shared genetics of immune-related diseases
A Zhernakova, CC Van Diemen… - Nature Reviews Genetics, 2009 - nature.com
Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …
immune-related disorders that further our understanding of the development and …
Genetic insights into common pathways and complex relationships among immune-mediated diseases
Shared aetiopathogenic factors among immune-mediated diseases have long been
suggested by their co-familiality and co-occurrence, and molecular support has been …
suggested by their co-familiality and co-occurrence, and molecular support has been …
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
EJ Rossin, K Lage, S Raychaudhuri, RJ Xavier… - PLoS …, 2011 - journals.plos.org
Genome-wide association studies (GWAS) have defined over 150 genomic regions
unequivocally containing variation predisposing to immune-mediated disease. Inferring …
unequivocally containing variation predisposing to immune-mediated disease. Inferring …
Emerging patterns of genetic overlap across autoimmune disorders
C Richard-Miceli, LA Criswell - Genome medicine, 2012 - Springer
Most of the recently identified autoimmunity loci are shared among multiple autoimmune
diseases. The pattern of genetic association with autoimmune phenotypes varies …
diseases. The pattern of genetic association with autoimmune phenotypes varies …
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease
(CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically …
(CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically …
Genetics of autoimmune diseases: perspectives from genome-wide association studies
Y Kochi - International immunology, 2016 - academic.oup.com
Genome-wide association studies (GWASs) for autoimmune diseases (ADs) have identified
many risk loci and have provided insights into the etiology of each disease. Some of these …
many risk loci and have provided insights into the etiology of each disease. Some of these …
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
PS Ramos, LA Criswell, KL Moser, ME Comeau… - PLoS …, 2011 - journals.plos.org
In spite of the well-known clustering of multiple autoimmune disorders in families, analyses
of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) …
of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) …