Transmembrane proteins in the sorting endosome are either recycled to their point of origin
or destined for lysosomal degradation. Lysosomal sorting is mediated by interaction of …

The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the
control of cellular functions. We previously identified three mammalian Vps (vacuolar protein …

Ubiquitin-dependent sorting of membrane proteins in endosomes directs them to lysosomal
degradation. In the case of receptors such as the epidermal growth factor receptor (EGFR) …

A ubiquitin-binding endosomal protein machinery is responsible for sorting endocytosed
membrane proteins into intraluminal vesicles of multivesicular endosomes (MVEs) for …

The endosomal sorting complex required for transport (ESCRT) complexes sort
ubiquitinated membrane proteins into multivesicular bodies, which is a key step in the …

The turnover of integral membrane proteins requires a specialized transport pathway
mediated by components of the endosomal sorting complex required for transport (ESCRT) …

Ubiquitylated developmental membrane signaling proteins are often internalized for
endocytic trafficking, through which endosomal sorting complexes required for transport …

The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …

The ubiquitin‐binding protein Hrs and endosomal sorting complex required for transport
(ESCRT)‐I and ESCRT‐III are involved in sorting endocytosed and ubiquitinated receptors …

To reach the lysosomes, down-regulated receptors such as the epidermal growth factor
receptor must first be sorted into internal vesicles of late endosomes (multivesicular bodies) …