Liver X receptor (LXR) agonists increase both total fecal sterol excretion and macrophage-
specific reverse cholesterol transport (RCT) in vivo. In this study, we assessed the effects of …

Background & Aims: Reverse cholesterol transport (RCT) is defined as high-density
lipoprotein (HDL)-mediated flux of excess cholesterol from peripheral cells to liver, followed …

Recent studies have indicated that direct intestinal secretion of plasma cholesterol
significantly contributes to fecal neutral sterol loss in mice. The physiological relevance of …

Objective—We previously reported that a systemic liver X receptor (LXR) agonist promoted
macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in …

Liver X receptor (LXR) activation promotes reverse cholesterol transport (RCT) in rodents
but has major side effects (increased triglycerides and LDL-cholesterol levels) in species …

Background—Liver X receptors (LXRs) are ligand-activated transcription factors involved in
the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown …

Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the
trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR …

The liver X receptors (LXRs) have been shown to affect lipoprotein plasma profile, lipid
metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated …

The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL)
formation and considered rate-controlling for reverse cholesterol transport. Expression of the …

Objective—The ability of high-density lipoprotein (HDL) particles to accept cholesterol from
peripheral cells, such as lipid-laden macrophages, and to transport cholesterol to the liver …