Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …

As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

The metabolism and homeostasis of the skeletal system have historically been considered
to be associated with the endocrine system. However, this view has been expanded with the …

Emerging evidence in the literature describes a physical and functional association between
the neural and skeletal systems that forms a neuro-osteogenic network. This communication …

Bones provide both skeletal scaffolding and space for hematopoiesis in its marrow. Previous
work has shown that these functions were tightly regulated by the nervous system. The …

The brain, which governs most, if not all, physiological functions in the body, from the
complexities of cognition, learning and memory, to the regulation of basal body temperature …

ABSTRACT Purpose/Aim: Alzheimer's disease (AD), the primary cause of dementia in the
elderly, is one of the leading age-related neurodegenerative diseases worldwide. While AD …

Nerves have been identified in bone. Their function has recently become the focus of
intense study. Metabolic control of bone is influenced by the nervous system. Potential …

Osteoporosis is well known to be a poly-factorial skeletal disorder characterized by a low
bone mineral density (BMD) at which the risk of developing fracture is remarkably increased …

Although the brain is well established as a master regulator of homeostasis in peripheral
tissues, central regulation of bone mass represents a novel and rapidly expanding field of …