Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems
NM Grindler, KH Moley - MHR: Basic science of reproductive …, 2013 - academic.oup.com
Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …
Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes
The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …
which development of the conceptus is compromised and the mechanisms responsible for …
Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role?
Insulin resistance is a key defect associated with obesity, type 2 diabetes and other
metabolic diseases. While a number of factors have been suggested to cause defects in …
metabolic diseases. While a number of factors have been suggested to cause defects in …
[HTML][HTML] Mitochondrial dysfunction in the offspring of obese mothers and it's transmission through damaged oocyte mitochondria: Integration of mechanisms
AL Elias-Lopez, O Vázquez-Mena… - Biochimica et Biophysica …, 2023 - Elsevier
In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …
Oocyte mitochondrial function and reproduction
Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors
Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …
programs the metabolism of offspring; however, the temporal and mechanistic origins of …
Oocyte mitochondria—Key regulators of oocyte function and potential therapeutic targets for improving fertility
The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …
production. This reliance on mitochondrial activity, together with the exclusively maternal …
Mitochondrial dysfunction in obesity and reproduction
M Das, C Sauceda, NJG Webster - Endocrinology, 2021 - academic.oup.com
Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …
Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice
WFA Marei, A Smits, O Mohey-Elsaeed, I Pintelon… - Scientific Reports, 2020 - nature.com
Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial
dysfunction plays a central role here, and most often inbred mouse models are used to study …
dysfunction plays a central role here, and most often inbred mouse models are used to study …
The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility
H Schatten, QY Sun, R Prather - Reproductive Biology and Endocrinology, 2014 - Springer
Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …
quality which is important for fertilization and development into viable offspring. Quality …
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