Amiodarone is a potent Class III antiarrhythmic drug. The N‐deethylation of amiodarone to
desethylamiodarone is known to be catalyzed by cytochrome P450 (CYP) 2C8. In the …

Human cytochrome P450 (CYP) isoforms involved in amiodarone N-deethylation were
identified, and the relative contributions of these CYP isoforms were evaluated in different …

Metabolism of amiodarone to its N-deethylated derivative was investigated on a bank of
human hepatic microsomal fractions, two of them lacking the CYP2D6 isozyme. Michaelis …

Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity.
Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N …

Cytochrome P450 3A4 (CYP3A4) is an important member of the cytochrome P450 enzyme
superfamily, with 33 allelic variants reported previously. Genetic polymorphisms of CYP3A4 …

PURPOSE. To evaluate the metabolism of amiodarone (AM) to desethylamiodarone (DEA)
by selected human and rat cytochrome P450, and the inhibitory effect of ketoconazole (KTZ) …

Aims To predict the drug interactions of amiodarone and other drugs, the inhibitory effects
and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and …

Experiments were conducted on three different human liver samples to identify the
cytochrome P450 isozyme which is involved in the biotransformation of the class III …

CYP2C9 substrates can exhibit both hyperbolic and atypical kinetic profiles, and their
metabolism can be activated or inhibited depending on the effector studied. CYP2C9 …

In this study, IC50 shift and time-dependent inhibition (TDI) experiments were carried out to
measure the ability of amiodarone (AMIO), and its circulating human metabolites, to …