This review discusses key findings indicating potential roles of the complement (C)-system
in chronic inflammation in Alzheimer's disease (AD) brain. Although there is no means to …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

Background Complement proteins and activation products have been found associated with
neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

The complement system provides an innate defence mechanism against pathogenic
microorganisms. Although viewed for many years as an immune-privileged organ, the …

A variety of inflammatory mediators including complement activation products, protease
inhibitors, and cytokines are colocalized with β-amyloid (Aβ) deposits in the Alzheimer's …

In Alzheimers's disease (AD) a disturbed balance between synthesis and removal of Aβ
leads to the formation of Aβ deposits and a reaction of the innate immune system. Little …

Molecular pathological studies of Alzheimer disease (AD) brain have revealed the presence
of a spectrum of inflammatory mediators. Epidemiological studies have indicated that the …