Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis
The incidence of melanoma is increasing over the years with a still poor prognosis and the
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …
[HTML][HTML] CAMKK2 defines ferroptosis sensitivity of melanoma cells by regulating AMPK‒NRF2 pathway
S Wang, X Yi, Z Wu, S Guo, W Dai, H Wang… - Journal of Investigative …, 2022 - Elsevier
Melanoma is the most lethal skin cancer caused by the malignant transformation of
epidermal melanocytes. Recent progress in targeted therapy and immunotherapy has …
epidermal melanocytes. Recent progress in targeted therapy and immunotherapy has …
Targeting ferroptosis in rhabdomyosarcoma cells
J Dächert, V Ehrenfeld, K Habermann… - … journal of cancer, 2020 - Wiley Online Library
Recent data suggest that rhabdomyosarcoma (RMS) cells might be vulnerable to oxidative
stress‐induced cell death. Here, we show that RMS are susceptible to cell death induced by …
stress‐induced cell death. Here, we show that RMS are susceptible to cell death induced by …
Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer
J Lee, JL Roh - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Ferroptosis is a newly discovered form of programmed cell death caused by redox-active
iron-mediated lipid peroxidation. Ferroptosis exhibits a unique morphological phenotype …
iron-mediated lipid peroxidation. Ferroptosis exhibits a unique morphological phenotype …
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …
biochemically and genetically distinct from other forms of cell death and that has emerged to …
The molecular mechanisms of regulating oxidative stress‐induced Ferroptosis and therapeutic strategy in tumors
J Zhu, Y Xiong, Y Zhang, J Wen, N Cai… - Oxidative Medicine …, 2020 - Wiley Online Library
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis,
necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron‐dependent …
necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron‐dependent …
Metabolic regulation of ferroptosis in the tumor microenvironment
NE Mbah, CA Lyssiotis - Journal of Biological Chemistry, 2022 - ASBMB
Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by
impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid …
impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid …
Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells
K Wang, Z Zhang, H Tsai, Y Liu, J Gao… - Cell Death & …, 2021 - nature.com
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-
dependent lipid peroxidation, has been implicated as a tumor-suppressor function for cancer …
dependent lipid peroxidation, has been implicated as a tumor-suppressor function for cancer …
Broadening horizons: the role of ferroptosis in cancer
The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
Nobiletin induces ferroptosis in human skin melanoma cells through the GSK3β-mediated Keap1/Nrf2/HO-1 signalling pathway
S Feng, Y Zhou, H Huang, Y Lin, Y Zeng, S Han… - Frontiers in …, 2022 - frontiersin.org
Melanoma is an aggressive malignant skin tumour with an increasing global incidence.
However, current treatments have limitations owing to the acquired tumour drug resistance …
However, current treatments have limitations owing to the acquired tumour drug resistance …