Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone‐Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and …
S Magdy Eldaly, D Salama Zakaria… - Chemistry & …, 2023 - Wiley Online Library
Synthesis of new anticancer candidates with protein kinases inhibitory potency is a major
goal of pharmaceutical science and synthetic research. This current work represents the …
goal of pharmaceutical science and synthetic research. This current work represents the …
Synthesis and molecular docking study of new thiazolidinones incorporating a benzoate moiety as anti-HepG2 cancer agents, EGFR inhibitors and apoptosis inducers
SM Eldaly, DS Zakaria, NH Metwally - 2023 - researchsquare.com
Synthesis of new anticancer candidates with protein kinases inhibitory potency is a major
goal of pharmaceutical science and synthetic research. This current work represents the …
goal of pharmaceutical science and synthetic research. This current work represents the …
Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone-Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and …
M Eldaly - Chemistry & Biodiversity, 2023 - europepmc.org
Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New
Thiazolidinone-Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and Apoptosis …
Thiazolidinone-Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and Apoptosis …
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
New thiazolidine-2, 4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies
Background VEGFR-2 has emerged as a prominent positive regulator of cancer
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives
AAE Mourad, NA Farouk, ESH El-Sayed, ARE Mahdy - Life Sciences, 2021 - Elsevier
Aims EGFR and VEGFR-2 have emerged as promising targets for cancer management as
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
[PDF][PDF] Synthesis, molecular modeling studies and biological evaluation of novel pyrazole derivatives as antitumor and EGFR inhibitors
S Walaa, NA Mohamed, S Weam, ES Nossier… - Int. J. Pharm …, 2016 - researchgate.net
In this study, a new series of 4-(5-methylisoxazol-3-ylamino) thiazole derivatives
incorporated with different heterocyclic moieties was synthesized and screened for their in …
incorporated with different heterocyclic moieties was synthesized and screened for their in …
Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2, 4-diones targeting VEGFR-2 and apoptosis pathway
We report herein, the design and synthesis of thiazolidine-2, 4-diones derivatives as new
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
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