Comparison of genome-wide DNA methylation patterns between antler precartilage and cartilage

J Wu, F Yang, X Wu, X Liu, D Zheng - Molecular Genetics and Genomics, 2023 - Springer
Deer antlers are the only mammalian organs that can fully regenerate after being lost and
provide a valuable model for cartilage development. As one of the best-studied epigenetic …

Identification of abnormally methylated–differentially expressed genes and pathways in osteoarthritis: a comprehensive bioinformatic study

L Zheng, W Chen, G Xian, B Pan, Y Ye, M Gu… - Clinical …, 2021 - Springer
Objectives To investigate abnormally methylated–differentially expressed genes (DEGs) and
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …

Understanding CpG methylation in the context of osteoarthritis

DA Young, C Bui, MJ Barter - Epigenomics, 2012 - Taylor & Francis
Worldwide, osteoarthritis (OA) affects approxi‑mately 40% of people older than 70 years and
is therefore the most common form of arthritis. OA is a complex degenerative disease of the …

Evolution and advancements in genomics and epigenomics in OA research: How far we have come

YFM Ramos, SJ Rice, SA Ali, C Pastrello… - Osteoarthritis and …, 2024 - Elsevier
Objective Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting
articulating joint tissues, resulting in local and systemic changes that contribute to increased …

[HTML][HTML] Epigenetic regulation of chondrocyte catabolism and anabolism in osteoarthritis

H Kim, D Kang, Y Cho, JH Kim - Molecules and cells, 2015 - Elsevier
Osteoarthritis (OA) is one of the most prevalent forms of joint disorder, associated with a
tremendous socioeconomic burden worldwide. Various non-genetic and lifestyle-related …

Epigenetics in osteoarthritis and its implication for future therapeutics

GI Im, YJ Choi - Expert opinion on biological therapy, 2013 - Taylor & Francis
Introduction: Changes occurring in the chondrocyte gene that control articular cartilage are
important for the onset and progression of osteoarthritis (OA). However, actual development …

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

J Rodríguez-Ubreva, C de la Calle-Fabregat… - Annals of the …, 2019 - ard.bmj.com
Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly
targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to …

Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation

L Jin, J Ma, Z Chen, F Wang, Z Li, Z Shang… - BMC Medical …, 2023 - Springer
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation.
However, a comprehensive regulatory network for OA-related microRNAs and DNA …

Epigenetics of osteoarticular diseases: recent developments

SB Roberts, E Wootton, L De Ferrari… - Rheumatology …, 2015 - Springer
A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …

The role of DNA methylation in common skeletal disorders

J Delgado-Calle, JA Riancho - Biology, 2012 - mdpi.com
Bone is a complex connective tissue characterized by a calcified extracellular matrix. This
mineralized matrix is constantly being formed and resorbed throughout life, allowing the …