Background Recently there has been increased interest in pancreatic cholesterol esterase
due to correlation between enzymatic activity in vivo and absorption of dietary cholesterol …

Pancreatic cholesterol esterase (CEase) is a serine hydrolase involved in the hydrolysis of
variety of lipids and transport of free cholesterol. In this study, pharmacophore hypotheses …

On the purpose of looking for better cholesterol absorption inhibitors, several trifluoromethyl
substituted ezetimibe analogs 1a–d were designed and synthesized. The key steps in the …

A series of thieno [1, 3] oxazin-4-ones and thieno [1, 3] thiazin-4-ones were synthesized and
investigated as inhibitors of the α/β hydrolases cholesterol esterase (CEase) and …

We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …

Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in
atherosclerosis and for the development of hypocholesterolemic agents, there are …

In a kinetic study, the interaction of bovine pancreatic cholesterol esterase (CEase) with
fused 1, 3-oxazin-4-ones and 1, 3-thiazin-4-ones was investigated, and the compounds …

Abstract Two new trans-(3R, 4R)-amino-β-lactam derivatives and their diastereoisomeric
mixtures were synthesized as ezetimibe bioisosteres and tested in in vitro and in vivo …

Ezetimibe (1), a strong β-lactamic cholesterol absorption inhibitor, was synthesized from (R)-
6-(4-fluorophenyl)-5, 6-dihydro-2 H-pyran-2-one 7. Independent pathways were analyzed in …

This study was aimed to analyze the effect of procyanidin B 2 (PC) and tannin acid (TA) on
the activities of cholesterol esterase (CEase) and the inhibitory mechanisms of enzymatic …