Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry
S Zhao, Y Wu, L Hu - Bioorganic Chemistry, 2022 - Elsevier
In this study, the concept of dynamic combinatorial chemistry (DCC) was applied to explore
novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates …
novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates …
Synthesis and biological evaluation of ezetimibe analogs as possible cholesterol absorption inhibitors
Y Wang, W Huang, H Zhang… - Letters in Drug Design & …, 2011 - ingentaconnect.com
In order to investigate the SAR of Ezetimibe analogs for cholesterol absorption inhibitions,
amide group and electron-deficient pyridine ring were introduced to the C-(3) carbon chain …
amide group and electron-deficient pyridine ring were introduced to the C-(3) carbon chain …
[HTML][HTML] Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors
T Dražić, V Sachdev, C Leopold, JV Patankar… - Bioorganic & medicinal …, 2015 - Elsevier
The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of
this class of compounds on the market today. The goal of this work was to synthesize new …
this class of compounds on the market today. The goal of this work was to synthesize new …
Cholesterol‐lowering activity of natural mono‐and sesquiterpenoid compounds in essential oils: A review and investigation of mechanisms using in silico protein …
T Bahr, G Butler, C Rock, K Welburn… - Phytotherapy …, 2021 - Wiley Online Library
Mono‐and sesquiterpenoids are the main chemical constituents of essential oils. Essential
oils and their constituents have received increasing attention for lipid‐lowering properties in …
oils and their constituents have received increasing attention for lipid‐lowering properties in …
Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors
JP Gotteland, C Loubat, B Planty, D Junquéro… - Bioorganic & medicinal …, 1998 - Elsevier
~'~~Nv~o~N-.sO2A r Page 1 BIOORGANIC & MEDICINAL CHEMISTRY LE'IT'ERS Bioorganic
& Medicinal Chemistry Letters 8 (1998) 1337-1342 Pergamon Sulfonamide Derivatives of …
& Medicinal Chemistry Letters 8 (1998) 1337-1342 Pergamon Sulfonamide Derivatives of …
2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4 phenyl ring
WD Vaccaro, R Sher, HR Davis Jr - Bioorganic & medicinal chemistry, 1998 - Elsevier
2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4
phenyl ring - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …
phenyl ring - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …
Selection and development of a route for cholesterol absorption inhibitor AZD4121
S Karlsson, JH Sörensen - Organic Process Research & …, 2012 - ACS Publications
The development of a synthetic route to the cholesterol absorption inhibitor AZD4121 is
presented. Key steps are a highly enantioselective CBS reduction, a stereospecific …
presented. Key steps are a highly enantioselective CBS reduction, a stereospecific …
Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461
S Dugar, N Yumibe, JW Clader, M Vizziano… - Bioorganic & Medicinal …, 1996 - Elsevier
Based on the metabolism of the potent cholesterol absorption inhibitor (−) SCH48461 and
structure activity relationship information, we designed and evaluated (−) SCH 53079. This …
structure activity relationship information, we designed and evaluated (−) SCH 53079. This …
Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors
T Ritter, L Kværnø, M Werder, H Hauser… - Organic & biomolecular …, 2005 - pubs.rsc.org
Enantio-and diastereoselective syntheses of a substituted oxazolidinone, isoxazoline and
pyrazoline as β-lactam surrogates are described. The substituted heterocycles were …
pyrazoline as β-lactam surrogates are described. The substituted heterocycles were …