Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity.
Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of …

Previous SAR studies of C-3 side chain modified analogs of (−)-SCH 48461, 1, 3, 4 as well
as information concerning the metabolic stability this series, enabled us to design a …

Chemical‐based common feature pharmacophore modelling of Niemann Pick C1 Like 1
inhibitors was performed to provide some insights on the important pharmacophore features …

Cassia obtusifolia Linn. have been used to improve vision, inflammatory diseases, and as
hepatoprotective agents and to promote urination from ancient times. In the present study …

Metabolism initiated SAR studies led to the discovery of a new class of potent 2-azetidinone
cholesterol absorption inhibitors. These studies found that a heteroatom at the para position …

The underlying principle of drug design in this paper is that the maximum retention of the
functional groups that exist in the marketed drug would provide a higher probability for …

β-Lactams have recently been identified as potent, highly efficacious cholesterol absorption
inhibitors (CAIs). The discovery, SAR, and asymmetric synthesis of this class of …

Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been
synthesized, and three of them were enantiomerically pure. All the new compounds were …

Our continued interest in developing novel, potent acyl-CoA: cholesterol acyltransferase
(ACAT) inhibitors, and our discovery of several active series of disubstituted urea ACAT …

The rhizomes of Alisma orientalis have been used for centuries in China and other Asian
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …