Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Essential oils constituents are a diverse family of low molecular weight organic compounds
with comprehensive biological activity. According to their chemical structure, these active …

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula,
led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16 …

Background Pancreatic cholesterol esterase has three proposed functions in the intestine: 1)
to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to …

Statins are cholesterol-lowering drugs with a mechanism of inhibiting 3-hydroxy-3-
methylglutaryl-CoA reductase, but long-term use can cause side effects. An example of a …

A molecular docking analysis has been carried out to examine the hypolipidemic property of
γ-sitosterol against five target proteins [acetoacetyl thiolase (PDB ID: 2 F2S), 3-(HMG-CoA) …

Excess lipid accumulation can initiate the development and progression of atherosclerotic
lesions, thus eventually leading to cardiovascular disease. Lipid‐lowering medication …

(3 R)-(3-Phenylpropyl)-1,(4 S)-bis (4-methoxyphenyl)-2-azetidinone (2, SCH 48461), a novel
inhibitor of intestinal cholesterol absorption, has recently been described by Burnett et al …

AIM:: Dietary cholesterol absorption, endogenous cholesterol synthesis and biliary
cholesterol excretion regulate whole body cholesterol balance as a result of …

This review is the first attempt at systematization and analysis of the literature data (covering
the last decade) on the chemical structures and specific activities of cholesterol-regulating …