Hyperpolarized 3He apparent diffusion coefficient MRI of the lung: Reproducibility and volume dependency in healthy volunteers and patients with emphysema

S Diaz, I Casselbrant, E Piitulainen… - Journal of Magnetic …, 2008 - Wiley Online Library
Purpose To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) 3He
gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and …

Effects of diffusion time on short‐range hyperpolarized 3He diffusivity measurements in emphysema

DS Gierada, JC Woods, AJ Bierhals… - Journal of Magnetic …, 2009 - Wiley Online Library
Purpose To characterize the effect of diffusion time on short‐range hyperpolarized 3He
magnetic resonance imaging (MRI) diffusion measurements across a wide range of …

Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes—initial experience

M Salerno, EE de Lange, TA Altes, JD Truwit… - Radiology, 2002 - pubs.rsna.org
PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic
resonance (MR) images of the lung in patients with emphysema and to determine whether …

Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema

JC Woods, CK Choong, DA Yablonskiy… - … in Medicine: An …, 2006 - Wiley Online Library
Diffusion MRI of hyperpolarized 3He shows that the apparent diffusion coefficient (ADC) of
3He gas is highly restricted in the normal lung and becomes nearly unrestricted in severe …

Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references

S Diaz, I Casselbrant, E Piitulainen… - European journal of …, 2009 - Elsevier
PURPOSE: To compare apparent diffusion coefficient (ADC) measurements from
hyperpolarized (HP) helium (3He)-magnetic resonance imaging (MRI) with quantitative data …

Diffusion‐weighted MRI of the lung with hyperpolarized helium‐3: a study of reproducibility

AE Morbach, KK Gast… - Journal of Magnetic …, 2005 - Wiley Online Library
Purpose To determine the reproducibility of several parameters of the ADC measurement by
calculating the scan‐to‐scan intrasubject variability. Materials and Methods Measurements …

Time-dependent hyperpolarized 3He diffusion MR imaging: initial experience in healthy and emphysematous lungs

M Salerno, JR Brookeman… - Proceedings of the 9th …, 2001 - cds.ismrm.org
Several studies have reported apparent diffusion coefficient (ADC) values of 3He gas in the
lung, however few have explored the dependence of these ADC values on the effective …

Clinical aspects of the apparent diffusion coefficient in 3He MRI: Results in healthy volunteers and patients after lung transplantation

A Bink, G Hanisch, A Karg, A Vogel… - Journal of Magnetic …, 2007 - Wiley Online Library
Purpose To measure the apparent diffusion coefficient (ADC) after inhalation of
hyperpolarized 3He in healthy volunteers and lung transplant recipients, and demonstrate …

Demonstration of an alveolar-size gradient in the healthy human lung: a study of the reproducibility of hyperpolarized 3He diffusion MRI

M Salerno, JR Brookeman, EE de Lange… - Proc Intl Soc Mag …, 2000 - cds.ismrm.org
Although the apparent diffusion coefficient (ADC) of 3He has been measured in the human
lung [1, 2, 3], no studies have determined the reproducibility of ADC values. Since the ADC …

Simultaneous measurement of pulmonary partial pressure of oxygen and apparent diffusion coefficient by hyperpolarized 3He MRI

J Yu, M Law, S Kadlecek, K Emami… - … in Medicine: An …, 2009 - Wiley Online Library
Abstract Hyperpolarized 3He (HP 3He) MRI shows promise to assess structural and
functional pulmonary parameters in a sensitive, regional, and noninvasive way. Structural …