Bone mass loss occurs with a decrease in osteoblast proliferation and differentiation, or the
enhancement of bone resorption, which further leads to the impairment of bone mineral …

Genistein, a major phytoestrogen of soy, is considered a potential drug for the prevention
and treatment of post-menopausal osteoporosis. Mounting evidence suggested a positive …

Total flavonoids in Herba epimedii (HEP) have been demonstrated to protect against bone
loss and bone deterioration associated with estrogen deficiency without exerting any …

Natural alkaloids are polycyclic, nitrogen-containing, and basic compounds obtained from
plants. In this review, the advances in bioactive alkaloids with respect to their chemical …

The major risk factor of postmenopausal osteoporosis is estrogen deficiency. Hormone
replacement therapy is efficacious against osteoporosis, but it induces several significant …

A pivotal role in osteoporosis development is played by radical oxygen species (ROS), the
increased production of which is related to inhibited osteoblastic activity and bone formation …

Flavonoids, a group of natural compounds found in a variety of vegetables and herbal
medicines, have been intensively reported on stimulating bone mineral density and bone …

A growing body of evidence highlights the properties of flavonoids in natural foods for
disease prevention. Due to their antioxidative, anti-inflammatory, and anti-carcinogenic …

Bone regeneration in osteoporosis and fragility fractures which are highly associated with
age remains a great challenge in the orthopedic field, even though the bone is subjected to …