Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of APOEε4
The heterogeneity of the older population suggests the existence of subsets of individuals
which share certain brain molecular features and respond differently to risk factors for …
which share certain brain molecular features and respond differently to risk factors for …
New insights on the genetic etiology of Alzheimer's and related dementia
C Bellenguez, F Küçükali, I Jansen, V Andrade… - MedRxiv, 2020 - medrxiv.org
Deciphering the genetic landscape of Alzheimer's disease (AD) is essential to define the
pathophysiological pathways involved and to successfully translate genomics to potential …
pathophysiological pathways involved and to successfully translate genomics to potential …
Genetic, clinical underpinnings of subtle early brain change along Alzheimer's dimensions
Alzheimer's disease (AD) is associated with heterogeneous atrophy patterns,, which are
increasingly manifested throughout the disease course, driven by underlying …
increasingly manifested throughout the disease course, driven by underlying …
Neuropathological and transcriptomic characteristics of the aged brain
JA Miller, A Guillozet-Bongaarts, LE Gibbons… - Elife, 2017 - elifesciences.org
As more people live longer, age-related neurodegenerative diseases are an increasingly
important societal health issue. Treatments targeting specific pathologies such as amyloid …
important societal health issue. Treatments targeting specific pathologies such as amyloid …
Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood …
HS Moon, A Mahzarnia, J Stout, RJ Anderson… - Brain Structure and …, 2024 - Springer
APOE allelic variation is critical in brain aging and Alzheimer's disease (AD). The APOE2
allele associated with cognitive resilience and neuroprotection against AD remains …
allele associated with cognitive resilience and neuroprotection against AD remains …
[HTML][HTML] Alzheimer's risk factors age, APOE genotype, and sex drive distinct molecular pathways
Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …
Genetic variation associated with human longevity and Alzheimer's disease risk act through microglia and oligodendrocyte cross-talk
Ageing is the greatest global healthcare challenge, as it underlies age-related functional
decline and is the primary risk factor for a range of common diseases, including …
decline and is the primary risk factor for a range of common diseases, including …
A genome-wide scan for common variants affecting the rate of age-related cognitive decline
Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic
conditions of aging, including neurodegenerative and vascular disease. Because common …
conditions of aging, including neurodegenerative and vascular disease. Because common …
Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex
The relationship between genetic variation and gene expression in individual brain cell
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups
Categorizing people with late-onset Alzheimer's disease into biologically coherent
subgroups is important for personalized medicine. We evaluated data from five studies (total …
subgroups is important for personalized medicine. We evaluated data from five studies (total …