[HTML][HTML] Zinc as a therapeutic agent in bone regeneration

JP O'Connor, D Kanjilal, M Teitelbaum, SS Lin… - Materials, 2020 - mdpi.com
Zinc is an essential mineral that is required for normal skeletal growth and bone
homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However …

[HTML][HTML] Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells

HJ Seo, YE Cho, T Kim, HI Shin… - Nutrition research and …, 2010 - synapse.koreamed.org
Zinc is an essential trace element required for bone formation, however not much has been
clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic …

[HTML][HTML] The role of zinc in bone tissue health and regeneration—a review

M Molenda, J Kolmas - Biological Trace Element Research, 2023 - Springer
Zinc is a micronutrient of key importance for human health. An increasing number of studies
indicate that zinc plays a significant role in bone tissue's normal development and …

Role of zinc in bone formation and bone resorption

M Yamaguchi - The Journal of Trace Elements in Experimental …, 1998 - Wiley Online Library
Zinc is essential for the growth of the human and other animals. Bone growth retardation is a
common finding in various conditions associated with zinc deficiency, suggesting a …

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

X Wen, J Wang, X Pei, X Zhang - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Zinc (Zn) is one of the most important trace elements in the human body and plays a key role
in various physiological processes, especially in bone metabolism. Zn-containing materials …

Zinc promotes osteoblast differentiation in human mesenchymal stem cells via activation of the cAMP-PKA-CREB signaling pathway

KH Park, Y Choi, DS Yoon, KM Lee, D Kim… - Stem cells and …, 2018 - liebertpub.com
The crucial trace element zinc stimulates osteogenesis in vitro and in vivo. However, the
pathways mediating these effects remain poorly understood. This study aimed to investigate …

Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation

M Yamaguchi, MN Weitzmann - Molecular and cellular biochemistry, 2011 - Springer
Zinc is essential for numerous biochemical pathways in the body and is known to
significantly affect the skeleton. Zinc has a profound effect on bone turnover promoting bone …

Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line

M Nagata, B Lönnerdal - The Journal of nutritional biochemistry, 2011 - Elsevier
Zinc (Zn) supplementation stimulates bone growth in Zn-deficient humans and animals. A
biphasic pattern of mineralization has been observed in cultured osteoblasts; an initiation …

[HTML][HTML] Serum zinc levels and multiple health outcomes: implications for zinc-based biomaterials

X Qu, H Yang, Z Yu, B Jia, H Qiao, Y Zheng, K Dai - Bioactive Materials, 2020 - Elsevier
Background Zinc-based biomaterials, including biodegradable metal, nanoparticles, and
coatings used in medical implants release zinc ions that may increase the whole-body and …

Osteoblast-mediated effects of zinc on isolated rat osteoclasts: inhibition of bone resorption and enhancement of osteoclast number

WR Holloway, FM Collier, RE Herbst, JM Hodge… - Bone, 1996 - Elsevier
Zinc is an important element in biology yet little is understood of its role in bone cell
metabolism and function. This study examined the effects of zinc on osteoclast (OC) function …