Experimental pneumonia models are important tools to study the pathophysiology of lung
inflammation caused by microbial infections and the efficacy of (novel) drugs. We have …

Apart from inadequate antimicrobial treatment, specific virulence factors contribute to the
high attributable mortality of infections caused by multidrug-resistant (MDR) Klebsiella …

Pneumonia is one of the leading causes of severe and occasionally life-threatening
infections. The physiopathology of pneumonia has been extensively studied, providing …

Klebsiella pneumoniae (K. pneumoniae) is a common cause of nosocomial infection, which
causing disseminated infections such as cystitis, pneumonia and sepsis. K. pneumoniae is …

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection
and validated its utility using a highly virulent wild-type strain and an avirulent capsular …

Summary Background Hypervirulent Klebsiella pneumoniae (hvKp) strains of capsule type
K1 and K2 cause invasive infections associated with hepatic abscesses, which can be …

Klebsiella pneumoniae colonizes mucosal surfaces of healthy humans and is responsible
for one third of all Gram-negative infections in hospitalized patients. K. pneumoniae is …

Animal infection models play significant roles in studying bacterial pathogenic mechanisms,
host pathogen interaction as well as evaluating drug and vaccine efficacies. We have been …

Klebsiella spp. are important pathogens of humans and companion animals such as cats
and dogs, capable of causing severe life-threatening diseases. The aim of this study was to …

Biological disease models can be difficult and costly to develop and use on a routine basis.
Particularly, in vivo lung infection models performed to study lung pathologies use to be …