[HTML][HTML] NLRP3 inflammasome and its inhibitors: a review
BZ Shao, ZQ Xu, BZ Han, DF Su, C Liu - Frontiers in pharmacology, 2015 - frontiersin.org
Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …
[HTML][HTML] Pharmacological inhibitors of the NLRP3 inflammasome
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …
which deal with a plethora of pathogenic products and cellular products associated with …
The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases
The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …
can be initiated in response to various exogenous or endogenous danger signals …
[HTML][HTML] Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …
[HTML][HTML] The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
X Zhan, Q Li, G Xu, X Xiao, Z Bai - Frontiers in Immunology, 2023 - frontiersin.org
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma - Pharmacological reviews, 2023 - ASPET
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
[HTML][HTML] Focus on the Role of NLRP3 Inflammasome in Diseases
R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases
X Zhang, Z Wang, Y Zheng, Q Yu… - International …, 2023 - spandidos-publications.com
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators
D Liu, X Zeng, X Li, C Cui, R Hou, Z Guo… - Biochemical …, 2020 - Elsevier
NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …
[HTML][HTML] NLRP3 ubiquitination—a new approach to target NLRP3 inflammasome activation
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …