Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
Small molecules for active targeting in cancer
For the purpose of this review, active targeting in cancer research encompasses strategies
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …
Engineering small molecule nanodrugs to overcome barriers for cancer therapy
Small molecule nanodrugs consisting of pure drugs, drug‐drug dimers, drug‐drug
conjugates, or drug derivatives could realize drug delivery by themselves without the aid of …
conjugates, or drug derivatives could realize drug delivery by themselves without the aid of …
Role of small molecule targeted compounds in cancer: progress, opportunities, and challenges
G Sun, D Rong, Z Li, G Sun, F Wu, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Research on molecular targeted therapy of tumors is booming, and novel targeted therapy
drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy …
drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy …
Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery
Traditional chemotherapy mostly relies on the use of cytotoxic agents, which are typically
unable to preferentially localize at the tumor microenvironment resulting in off-target toxicity …
unable to preferentially localize at the tumor microenvironment resulting in off-target toxicity …
Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery
SR MacEwan, DJ Callahan, A Chilkoti - Nanomedicine, 2010 - Taylor & Francis
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy
of chemotherapeutics, largely through passive accumulation provided by the enhanced …
of chemotherapeutics, largely through passive accumulation provided by the enhanced …
Recent progress of supramolecular chemotherapy based on host–guest interactions
M Yan, S Wu, Y Wang, M Liang, M Wang… - Advanced …, 2024 - Wiley Online Library
Chemotherapy is widely recognized as an effective approach for treating cancer due to its
ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional …
ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional …
Robust and smart polypeptide-based nanomedicines for targeted tumor therapy
C Deng, Q Zhang, J Guo, X Zhao, Z Zhong - Advanced drug delivery …, 2020 - Elsevier
Nanomedicines based on synthetic polypeptides are among the most versatile and
advanced platforms for tumor therapy. Notably, several polypeptide-based nanodrugs are …
advanced platforms for tumor therapy. Notably, several polypeptide-based nanodrugs are …
Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy
CY Ang, SY Tan, Y Zhao - Organic & biomolecular chemistry, 2014 - pubs.rsc.org
Cancer is currently one of the major diseases that has gained a lot of scientific attention.
Conventional cancer therapeutics involve surgical removal of tumors from patients followed …
Conventional cancer therapeutics involve surgical removal of tumors from patients followed …
[HTML][HTML] Peptide-decorated polymeric nanomedicines for precision cancer therapy
The advancement of tissue and cell-specific drug delivery systems is a key to precision
cancer therapy. Peptides, with easy synthesis, low immunogenicity and biological functions …
cancer therapy. Peptides, with easy synthesis, low immunogenicity and biological functions …