The structural biology of type IV secretion systems

R Fronzes, PJ Christie, G Waksman - Nature Reviews Microbiology, 2009 - nature.com
Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both
Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from …

[HTML][HTML] Type three secretion system in attaching and effacing pathogens

MO Gaytán, VI Martínez-Santos, E Soto… - Frontiers in cellular …, 2016 - frontiersin.org
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic
bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes …

A NanoLuc luciferase‐based assay enabling the real‐time analysis of protein secretion and injection by bacterial type III secretion systems

S Westerhausen, M Nowak… - Molecular …, 2020 - Wiley Online Library
The elucidation of the molecular mechanisms of secretion through bacterial protein
secretion systems is impeded by a shortage of assays to quantitatively assess secretion …

Probing the in vivo dynamics of type I protein secretion complex association through sensitivity to detergents

S Cescau, L Debarbieux… - Journal of bacteriology, 2007 - Am Soc Microbiol
The Serratia marcescens hemophore is secreted by a type I secretion system consisting of
three proteins: a membrane ABC protein, an adaptor protein, and the TolC-like outer …

Imaging the assembly, structure and activity of type III secretion systems

J Enninga, I Rosenshine - Cellular microbiology, 2009 - Wiley Online Library
The type III secretion system (T3SS) is a sophisticated molecular machinery of Gram‐
negative bacteria used to 'inject'(translocate) bacterial proteins (effectors) into eukaryotic …

Type II secretion: from structure to function

TL Johnson, J Abendroth, WGJ Hol… - FEMS microbiology …, 2006 - academic.oup.com
abstract Gram-negative bacteria use the type II secretion system to transport a large number
of secreted proteins from the periplasmic space into the extracellular environment. Many of …

Molecular characterization of the InvE regulator in the secretion of type III secretion translocases in Salmonella enterica serovar Typhimurium

JS Kim, JI Jang, JS Eom, CH Oh, HG Kim… - …, 2013 - microbiologyresearch.org
The type III secretion systems (T3SSs) are exploited by many Gram-negative pathogenic
bacteria to deliver a set of effector proteins into the host cytosol during cell entry. The T3SS …

The inner rod of virulence‐associated type III secretion systems constitutes a needle adapter of one helical turn that is deeply integrated into the system's export …

CE Torres‐Vargas, T Kronenberger… - Molecular …, 2019 - Wiley Online Library
Type III secretion injectisomes are essential virulence factors for many pathogenic bacteria
by mediating the transport of effector proteins into eukaryotic host cells. The secretion …

High-throughput screening of type III secretion determinants reveals a major chaperone-independent pathway

NH Ernst, AZ Reeves, JE Ramseyer, CF Lesser - MBio, 2018 - Am Soc Microbiol
Numerous Gram-negative bacterial pathogens utilize type III secretion systems (T3SSs) to
inject tens of effector proteins directly into the cytosol of host cells. Through interactions with …

Organization and coordinated assembly of the type III secretion export apparatus

S Wagner, L Königsmaier… - Proceedings of the …, 2010 - National Acad Sciences
Type III protein secretion systems are unique bacterial nanomachines with the capacity to
deliver bacterial effector proteins into eukaryotic cells. These systems are critical to the …