Comparison of various chromatographic systems for analysis of cytisine in human serum, saliva and pharmaceutical formulation by HPLC with diode array …

K Wróblewski, A Petruczynik, T Tuzimski, D Przygodzka… - Molecules, 2019 - mdpi.com
Background: Identification and quantitative determination of cytisine, especially in biological
samples and pharmaceutical formulations, is still a difficult analytical task. Cytisine is an …

Development and validation of LC-MS/MS method for determination of cytisine in human serum and saliva

K Wróblewski, M Szultka-Młyńska, RJ Courtney… - International Journal of …, 2023 - mdpi.com
Cytisine (CYT) is a quinolizidine alkaloid used for nicotine addiction treatment. Recent
clinical trial data regarding cytisine confirm its high effectiveness and safety as a smoking …

[PDF][PDF] Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits

H Astroug, R Simeonova, L Kassabova… - Interdisciplinary …, 2010 - sciendo.com
The aim of this study is to develop a sensitive HPLC method for the quantitative
determination of cytisine in serum and to characterize the pharmacokinetic behaviour of …

Determination of Cytisine and N-Methylcytisine from Selected Plant Extracts by High-Performance Liquid Chromatography and Comparison of Their Cytotoxic Activity

A Petruczynik, K Wróblewski, J Misiurek, T Plech… - Toxins, 2020 - mdpi.com
Quinolizidine alkaloids exhibit various forms of biological activity. A lot of them were found in
the Leguminosae family, including Laburnum and Genista. The aim of the study was the …

[HTML][HTML] Cytisine: state of the art in pharmacological activities and pharmacokinetics

X Wang, J Yang, P Huang, D Wang, Z Zhang… - Biomedicine & …, 2024 - Elsevier
Cytisine is a naturally occurring bioactive compound, an alkaloid mainly isolated from
legume plants. In recent years, various biological activities of cytisine have been explored …

[HTML][HTML] Cytisine and cytisine derivatives. More than smoking cessation aids

C Gotti, F Clementi - Pharmacological research, 2021 - Elsevier
Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

Synthesis of N-[2′-Bromo-4′-Methoxy-3′-(β-Cytisinylethoxy)Benzyl]Cytisine

SB Rakhimov, VI Vinogradova… - Chemistry of Natural …, 2016 - Springer
The new cytisine derivatives N-(3′-β-bromoethoxy-4′-methoxy-2′-bromobenzyl) cytisine
and N-[2′-bromo-4′-methoxy-3′-(β-cytisinylethoxy) benzyl] cytisine were prepared from …

[PDF][PDF] Development and validation of a RP-HPLC method for determination of citicoline monosodium in human plasma

SK Bindaiya, K Sahu, M Bhaisare… - Latin Am. J …, 2011 - researchgate.net
A sensitive and specific high performance reversed phase liquid chromatographic method
was developed for quantification of citicoline monosodium (CTM) in human plasma. The …

Analysis of terpene compounds in Cimicifuga foetida L. by reversed-phase high-performance liquid chromatography with evaporative light scattering detection

L Kong, X Li, H Zou, H Wang, X Mao, Q Zhang… - … of Chromatography A, 2001 - Elsevier
An RP-HPLC method with evaporative light scattering detection (ELSD) was developed for
the analysis of terpene compounds in traditional Chinese medicine. Actein, 27-deoxyactein …

Plasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation

SH Jeong, J Sheridan, D Newcombe, M Tingle - Xenobiotica, 2018 - Taylor & Francis
Cytisine is a plant alkaloid that is a partial agonist for the α4β2-nAChRs and is used as an
aid to smoking cessation. To date, there are no published data on cytisine concentrations in …