Abstract Cyclooxygenase-2 (COX-2) gene overexpression is suggested to play important
roles in colorectal tumorigenesis. Epidemiological studies revealed that nonsteroidal anti …

The expression levels of cyclooxygenase (COX)‑2 and the prostaglandin E2 (PGE2) content
have been associated with poor prognosis in patients with colorectal cancer (CRC). There is …

Colorectal cancer is the most common cancer in Western countries and the second leading
cause of cancerrelated death. Sporadic lesions represent 75-80% of all colorectal cancer …

There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …

Growing evidence shows that chronic inflammation drives the progression of colorectal
cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes …

Bioactive metabolites downstream of cyclooxygenase‐2 (COX‐2) generated prostaglandin
H2 (PGH2), in particular prostaglandin E2 (PGE2), are thought to play critical roles during …

Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk
and mortality from colorectal cancer in humans. All of the mechanism (s) by which …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Colorectal cancer is the second leading cause of death from cancer in the United States.
Continuous use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has …

The importance of the prostaglandin (PG) synthesis pathway, particularly the rate-limiting
enzymatic step catalyzed by cyclooxygenase, to colorectal carcinogenesis and development …