Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit the cyclooxygenases (COXs)
and suppress prostaglandin (PG) synthesis have been used widely as anti-inflammatory …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

In this brief overview we discuss the association between Wnt signaling and colon cell
biology and tumorigenesis. Our current understanding of the role of Apc in the β-catenin …

There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2
expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE2 acts …

Elevated levels of prostaglandin E2 (PGE2) are often found in colorectal cancers. Thus,
nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 (COX-2) …

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA.
Colorectal cancer progression and metastasis depends on the orchestration of the aberrant …

Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs)
have been implicated in the development and progression of colorectal cancer (CRC) …

The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the
regulation of Wnt signaling; however, APC also controls other cellular processes including …

Early experiments performed during 1980s and 1990s using carcinogen-induced rat
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …