Novel Synthetic (S,S) and (R,R)-Secoisolariciresinol Diglucosides (SDGs) Protect Naked Plasmid and Genomic DNA From Gamma Radiation Damage

OP Mishra, R Pietrofesa… - Radiation …, 2014 - meridian.allenpress.com
Secoisolariciresinol diglucoside (SDG) is the major lignan in wholegrain flaxseed. However,
extraction methods are complex and are associated with low yield and high costs. Using a …

[HTML][HTML] Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS-A novel …

OP Mishra, AV Popov, RA Pietrofesa… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Secoisolariciresinol diglucoside (SDG), the main lignan in whole grain
flaxseed, is a potent antioxidant and free radical scavenger with known radioprotective …

Synthesis and antioxidant evaluation of (S, S)-and (R, R)-secoisolariciresinol diglucosides (SDGs)

OP Mishra, N Simmons, S Tyagi, R Pietrofesa… - Bioorganic & medicinal …, 2013 - Elsevier
Abstract Secoisolariciresinol diglucosides (SDGs)(S, S)-SDG-1 (major isomer in flaxseed)
and (R, R)-SDG-2 (minor isomer in flaxseed) were synthesized from vanillin via …

Radioprotection of DNA by glycyrrhizic acid through scavenging free radicals

NM Gandhi, DK Maurya, V Salvi, S Kapoor… - Journal of radiation …, 2004 - jstage.jst.go.jp
Gamma-radiation induced strand breaks in plasmid pBR322 DNA. Glycyrrhizic acid (GZA)
protected plasmid DNA from radiation-induced strand breaks, as the disappearance of super …

[HTML][HTML] The flaxseed-derived lignan phenolic secoisolariciresinol diglucoside (SDG) protects non-malignant lung cells from radiation damage

A Velalopoulou, S Tyagi, RA Pietrofesa… - International journal of …, 2015 - mdpi.com
Plant phenolic compounds are common dietary antioxidants that possess antioxidant and
anti-inflammatory properties. Flaxseed (FS) has been reported to be radioprotective in …

Cyto-genotoxicity assessment of potential radioprotector, 3, 3′-diselenodipropionic acid (DSePA) in Chinese Hamster Ovary (CHO) cells and human peripheral …

RK Chaurasia, S Balakrishnan, A Kunwar… - … /Genetic Toxicology and …, 2014 - Elsevier
Our previous study showed that 3, 3′-diselenodipropionic acid (DSePA), a simple, stable,
and water-soluble organoselenium exhibiting glutathione peroxidase (GPx)-like activity …

[PDF][PDF] Antioxidant potential of secoisolariciresinol diglucoside isolated from different fractions of flaxseeds

J Rajesha, MA Harish, M Basavaraj, MD Shylaja… - Seed Sci …, 2008 - academia.edu
Flaxseed lignan (secoisolariciresinol diglucoside; SDG) was isolated from dehulled flaxseed
fractions such as hull, endosperm and flour of LVF-01 and GVF-03 varieties and were …

Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage

A Khan, K Manna, C Bose, M Sinha… - … Journal of Radiation …, 2013 - Taylor & Francis
Purpose: To evaluate the protective effect of gossypetin (GTIN) against gamma (γ)-radiation-
mediated DNA damage. Materials and methods: Increasing concentrations (10–150 μM) of …

Semiquinone glucoside derivative provides protection against γ‐radiation by modulation of immune response in murine model

S Mishra, DD Patel, DD Bansal… - Environmental …, 2016 - Wiley Online Library
Present study was undertaken to evaluate radioprotective and immunomodulatory activities
of a novel semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM‐1 in …

Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucoside

SS Moree, J Rajesha - Molecular and cellular biochemistry, 2013 - Springer
The present study was designed to evaluate the in vitro and in vivo ameliorative antioxidant
potential of secoisolariciresinol diglucoside (SDG). In vitro antioxidant activity of synthetic …