Publisher Summary This chapter discusses the mechanisms of programmed cell death
(PCD). In many different examples of PCD, regardless of the cell type involved and …

Death of some cells in the mammalian body is clearly programmed. In the immune system
there are many examples of programmed cell death, during development of lymphocytes as …

Apoptosis, or programmed cell death, is a series of controlled sequential events resulting in
the demise of cells without invoking an inflammatory response. It is a naturally occurring …

Programmed cell death or apoptosis occurs under physiological conditions as a result of
physiological effectors. It is a relatively slower process and requires active participation of …

Activation-induced apoptosis has been proposed as a mechanism for purging the immune
repertoire of anti-self specificities, not only in development but also during the generation of …

The progressive acceptance of active cell death by apoptosis' as a fundamental aspect of
the behaviour of normal cells has had a significant impact on many areas of biology …

The immune system provides good models for cell death, a phenomenon now recognized to
be of fundamental importance in many fields of biology. Cell death is strikingly polymorphic …

Programmed cell death (PCD) is currently one of the most intensively studied areas in cell
biology. Substantial evidence now exists demonstrating the integral role of PCD in many …

It is known that all living organisms are mortal. For many decades, the main interest of
researchers has been focused on the investigation of proliferation, differentiation and other …

The cells of a multicellular organism are members of a highly organized community. The
number of cells in this community is tightly regulated—not simply by controlling the rate of …