Nonviral gene delivery has been gaining considerable attention recently. Although the
efficacy of DNA transfection, which is a major concern, is low in nonviral vector-mediated …

Silica nanoparticles were prepared in a microemulsion system, using polyoxyethylene
nonylphenyl ether/cyclohexane/ammonium hydroxide. The surface charge of the particle …

Silica nanoparticles are attractive candidates for the development of safe and efficient non-
viral gene carriers, owing to their controlled morphologies, potential of facile surface …

We synthesised silica nanoparticles (SiNP) with covalently linked cationic surface
modifications and demonstrated their ability to electrostatically bind, condense and protect …

The application of nanotechnology to biomedical research is expected to have a major
impact leading to the development of new types of diagnostic and therapeutic tools. One …

Background The objective of this research was to design an effective gene delivery system
composed of cationic solid lipid nanoparticles (SLNs), protamine, and Deoxyribonucleic acid …

The transfer of genes into cells, both in vitro and in vivo, is critical for studying gene function
and conducting gene therapy. Methods that utilize viral and nonviral vectors, as well as …

The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface
oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to …

Chitosan (Cs) is a natural cationic polysaccharide that has shown potential as non-viral
vector for gene delivery because of its biocompatibility and low toxicity. However, chitosan …

Cationic solid lipid nanoparticles (SLN) have recently been suggested for non-viral gene
delivery, as these particles consist of well tolerated substances, can bind DNA directly via …