Gene therapy has long been regarded a promising treatment for many diseases, whether
acquired (such as AIDS or cancer) or inherited through a genetic disorder. A drug based on …

Purpose. To optimize gene delivery of SLN-based gene vectors by incorporation of a dimeric
HIV-1 TAT peptide (TAT 2) into SLN gene vectors. Methods. Plasmid DNA was complexed …

Several advanced in vitro and in vivo studies have proved the broad potential of cationic
solid lipid nanoparticles (SLN) as nonviral vectors. However, a few data are available about …

Non-viral gene therapy vectors are highly desirable tools for the introduction of DNA into
cells; they have better safety profiles than viral methods of delivery and are more amenable …

The present study aimed at developing a new approach in gene delivery of calcium
phosphate nanoparticles through simulated body fluid (CaP-SBF). The physicochemical and …

Chemotherapeutics that can trigger immunogenic cell death (ICD) and release tumor-
specific antigens are effective on treating a variety of cancers. The codelivery of …

In somatic gene therapy, new concepts for the transfer of DNA into specific cell nuclei are of
interest. Inorganic nanoparticles have an interesting potential as DNA carrier system due to …

In spite of significant advances in early detection and combined treatments, a number of
cancers are often diagnosed at advanced stages and thereby carry a poor prognosis …

For successful gene therapy, expansion of appropriate gene delivery systems could be one
of the factors of major significance. Gene therapy provides large opportunities for treating …

A defined change in formulation components affects the physical and chemical
characteristics of cationic liposomes (CLs) carriers in many ways. Therefore, a great degree …