The Duffy antigen receptor for chemokines: structural analysis and expression in the brain

R Horuk, A Martin, J Hesselgesser… - Journal of leukocyte …, 1996 - Wiley Online Library
The Duffy antigen receptor for chemokines (DARC) is expressed in human erythrocytes and
on endothelial cells lining postcapillary venules in kidney and spleen. DARC is a …

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

SC Peiper, ZX Wang, K Neote, AW Martin… - The Journal of …, 1995 - rupress.org
The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions
not only as a promiscuous chemokine receptor but also as a receptor for the malarial …

The Promiscuous Chemokine Binding Profile of the Duffy Antigen/Receptor for Chemokines Is Primarily Localized to Sequences in the Amino-terminal Domain (∗)

L Zhao-hai, W Zi-xuan, R Horuk, J Hesselgesser… - Journal of Biological …, 1995 - ASBMB
The Duffy antigen (DARC) is a promiscuous chemokine receptor that also binds
Plasmodium vivax. DARC belongs to a family of heptahelical chemokine receptors that …

Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor

K Neote, JY Mak, LFJ Kolakowski, TJ Schall - 1994 - ashpublications.org
The Duffy blood group antigen has been postulated to be a receptor on red blood cells
(RBCs) for the malarial parasite Plasmodium vivax and a promiscuous receptor for the …

The Duffy protein: a malarial and chemokine receptor

AO Pogo, A Chaudhuri - Seminars in hematology, 2000 - Elsevier
A major advance towards understanding the Duffy blood group system has been achieved
with the cloning of FY, a single-copy gene located in the 1q22→ q23 region of chromosome …

Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)

TC Dawson, AB Lentsch, Z Wang… - Blood, The Journal …, 2000 - ashpublications.org
Duffy antigen/receptor for chemokines (DARC) is a promiscuous receptor for chemokines
that is required for Plasmodium vivax infection of erythroid cells. This receptor is expressed …

Contribution of Duffy antigen to chemokine function

A Rot - Cytokine & growth factor reviews, 2005 - Elsevier
In addition to classical G protein-coupled receptors (GPCRs), a group of alternative,“silent”
chemokine receptors has recently been identified. These serpentine molecules are not …

Structure–function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites

C Tournamille, A Filipe, K Wasniowska… - British journal of …, 2003 - Wiley Online Library
The Duffy antigen/receptor for chemokines (DARC), a seven‐transmembrane glycoprotein
carrying the Duffy (Fy) blood group, acts as a widely expressed promiscuous chemokine …

Deletion of the Murine Duffy Gene (Dfy) Reveals that the Duffy Receptor Is Functionally Redundant

H Luo, A Chaudhuri, V Zbrzezna, Y He… - Molecular and cellular …, 2000 - Taylor & Francis
All of the antigenic determinants of the Duffy blood group system are in a glycoprotein (gp-
Fy), which is encoded by a single-copy gene (FY) located on chromosome 1. gp-Fy is also …

Close association of the first and fourth extracellular domains of the Duffy antigen/receptor for chemokines by a disulfide bond is required for ligand binding

C Tournamille, C Le Van Kim, P Gane… - Journal of Biological …, 1997 - ASBMB
It has been demonstrated that the promiscuous chemokine binding profile of the
Duffyantigen/receptor for chemokines (DARC) is given by its extracellular NH 2-terminal …