Forskolin, a diterpene that activates rapidly adenylate cyclase activity in several somatic cell
systems, prevents spontaneous meiotic maturation of denuded mouse oocytes (ED50 of …

The diterpene, forskolin, is a potent and reversible inhibitor of progesterone-induced meiosis
in Xenopus laevis oocytes (ED50 of inhibition∼ 3 μM). Forskolin alone increases cAMP …

Mouse oocytes are reversibly inhibited from resuming meiotic maturation in vitro by cAMP
phosphodiesterase inhibitors such as 3-isobutyl-1-methyl xanthine (IBMX) and cAMP …

Guanyl nucleotide binding‐proteins, or G‐proteins, are ubiquitous molecules that are
involved in cellular signal transduction mechanisms. Because a role has been established …

In the follicles of the mammalian and amphibian ovary, oocyte maturation is arrested at the
prophase of the first meiotic division. Prior to ovulation, oocytes reenter the cell cycle …

The present study was undertaken to assess the role of alterations of intraoocyte cAMP
concentrations in the meiotic maturation of isolated and follicle-enclosed oocytes. In isolated …

Mammalian oocytes are arrested at prophase of the first meiotic division before induction of
maturation by the preovulatory LH surge. In vitro, oocyte maturation occurs spontaneously …

Mammalian oocytes are arrested at the diplotene phase of the first meiotic division until
ovulation. In the mouse, germinal vesicle breakdown (GVBD) and progression to metaphase …

The adenylate cyclase activator forskolin was used to study the role of cAMP for oocyte
meiosis and follicular steroid secretion. Follicular and cumulus cAMP production was …

Cumulus cell‐enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were
obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats …