Impaired regulation of cholesterol metabolism increases the proliferation of hematopoietic
stem and progenitor cells in both the bone marrow and the spleen. Recent findings identified …

Cardiovascular diseases (CVDs) incidence is becoming higher. This fact is promoted by
metabolic disorders such as obesity, and aging. Atherosclerosis is the underlying cause of …

Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …

Atherosclerosis causing heart attack and stroke is the leading cause of death in the modern
world. Therapy for end-stage atherosclerotic disease using CD34+ hematopoietic cells has …

Monocytosis and neutrophilia are frequent events in atherosclerosis. These phenomena
arise from the increased proliferation of hematopoietic stem and multipotential progenitor …

Atherosclerosis is a chronic inflammatory disease driven by lipids and other atherogenic
factors. It is characterized by a dynamic and complex pathological process of bone marrow …

Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …

BACKGROUND: Aging represents the most powerful risk for the development of
atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by …

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …