The prevailing view of canonical Wnt signaling emphasizes the role of beta-catenin acting
downstream of Wnt activation to regulate transcriptional activity. However, emerging …

Wnt signaling pathways have fundamental roles in animal development and tumor
progression. Here, employing Xenopus embryos and mammalian cell lines, we report that …

Wnt/β-catenin signaling is activated repeatedly during an animal's lifespan, and it controls
gene expression through its essential nuclear effector, β-catenin, to regulate …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal
transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can …

Wnt signaling controls important aspects of animal development, and its deregulation has
been causally linked to cancer. Transduction of Wnt signals entails the association of β …

The Wnt signaling pathway provides key information during development of vertebrates and
invertebrates, and mutations in this pathway lead to various forms of cancer. Wnt binding to …

Summary p120-catenin is an Arm repeat protein that interacts with varied components such
as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite …

Wnt/β‐catenin signaling is an important cell‐to‐cell signaling mechanism that controls gene
expression during embryonic development and is critically implicated in human diseases …

TeS nucleus recently shown to be required for Wnt signaling (Wnt is the vertebrate
counterpart ofwingless). As with Wnt, ectopic overex-pression off-catenin mRNA induces a …