Insulin dependent diabetes mellitus (IDDM) is associated with several complications
including painful diabetic neuropathy. Previous animal and human studies have indicated …

Insulin-dependent diabetes mellitus (IDDM) is associated with several complications,
including painful diabetic neuropathy. Both animal and human investigations suggest an …

Pain threshold was assessed via tail flick latency in alloxan-diabetic, streptozotocin-diabetic,
BB/W-diabetic, and control laboratory rats. In addition, tail flick latency was determined …

Previous animal and human studies have indicated that nociceptive thresholds are
decreased by acute hyperglycemia. The results of these studies may be challenged due to …

Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

Pain threshold was assessed via tail flick latency in streptozotocin diabetic rats following a 1-
month period of either good or poor diabetic control. Additionally, tail flick latencies were …

Neuropathic pain in diabetics is characterized by both hyperalgesia and allodynia. This is
attributed to both uncontrolled glycemia and the further complications which it leads to. We …

Hyperactivity of nociceptive C-fibers has been recently described in diabetic BB/Wistar rats.
This study assesses the association of hyperalgesia, using an analgesy-meter, with elevated …

Diabetic neuropathic hyperalgesia is one of the most common diabetes complications. The
physiopathological mechanism of hyperalgesia and the reason by which this condition …

Animal studies have suggested an altered response to opiate agonists and antagonists as
well as an altered pain threshold in diabetic animals. In the studies reported herein, a 50 g …