Due to that at present, the majority of diseases are associated with alterations in oxidative
stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …

Physiological concentrations of reactive oxygen species (ROS) play vital roles in various
normal cellular processes, whereas excessive ROS generation is central to disease …

Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance
to oxidants, serves as one of the key defensive factors against a range of pathological …

Nrf2 regulates redox homeostasis in cells by coordinately regulating a range of antioxidant
enzymes and proteins. An increase in oxidative stress is one of the hallmarks of aging, and …

The transcription factor (nuclear factor-erythroid 2 p45-related factor 2, NRF2) is a master
regulator of the cellular response to oxidative insults. While antioxidant response enzymes …

Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …

Organisms have evolved sophisticated and redundant mechanisms to manage oxidative
and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for …