Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+ Cells In Vitro

A Tripp, Y Liu, M Sieburg, J Montalbano… - Journal of …, 2003 - Am Soc Microbiol
MATERIALS AND METHODS Cell lines. 293T and HeLa cells were cultured in Dulbeccos
modified Eagle medium (DMEM)(Gibco-BRL, Grand Island, NY) with 10% heat-inactivated …

Autocrine role of macrophage inflammatory protein-1 β in human T-cell lymphotropic virus type-I tax-transfected Jurkat T-cells

V Sharma, SL Lorey - Biochemical and Biophysical Research …, 2001 - Elsevier
The interaction of human T-cell lymphotropic virus I (HTLV-I) tax gene with host cell factors
plays an important role in the maintenance of the transformed state. There have been …

PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo

L Xie, B Yamamoto, A Haoudi, OJ Semmes, PL Green - Blood, 2006 - ashpublications.org
HTLV-1 cellular transformation and disease induction is dependent on expression of the
viral Tax oncoprotein. PDZ is a modular protein interaction domain used in organizing …

Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells

MD Dodon, Z Li, S Hamaia… - Journal of general …, 2004 - microbiologyresearch.org
Tax protein of human T-cell leukaemia virus type 1 (HTLV-1) induces the expression of
several cellular genes that are involved in T cell activation and proliferation. In this study, it …

The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter

YM Kim, N Sharma, JK Nyborg - Journal of virology, 2008 - Am Soc Microbiol
The etiology of human T-cell leukemia virus type 1 (HTLV-1)-induced adult T-cell leukemia
is linked to the expression of the viral oncoprotein Tax. Although the mechanism of retroviral …

The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax

SA Chevalier, L Meertens, C Pise-Masison, S Calattini… - Oncogene, 2006 - nature.com
Human T-cell leukemia virus and simian T-cell leukemia virus (STLV) form the primate T-cell
lymphotropic viruses group. Human T-cell leukemia virus type 1 and type 2 (HTLV-1 and …

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

E Pérès, J Blin, EP Ricci, M Artesi, V Hahaut… - PLoS …, 2018 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T …

Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells

M Imai, M Higuchi, H Kawamura, M Yoshita… - Virus Genes, 2013 - Springer
While human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell
leukemia, a close relative, HTLV-2, is not associated with any leukemia. HTLV-1 and HTLV …

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

M Higuchi, M Fujii - Retrovirology, 2009 - Springer
While the human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell
leukemia/lymphoma (ATL), to date, its close relative HTLV-2 is not associated with ATL or …

Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells

HC Lin, CS Dezzutti, RB Lal, AB Rabson - Journal of virology, 1998 - Am Soc Microbiol
Expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated both by the HTLV-1
Tax transactivator and by cellular transcriptional factors binding to the viral long terminal …