Erlotinib, gefitinib, or chemotherapy for EGFR mutation-positive lung cancer?
T Mitsudomi - The Lancet Oncology, 2011 - thelancet.com
Clinical practice in non-small-cell lung cancer (NSCLC) has changed greatly since the
introduction of EGFR tyrosine kinase inhibitors (TKIs). Subsequent discovery of activating …
introduction of EGFR tyrosine kinase inhibitors (TKIs). Subsequent discovery of activating …
EGFR testing in lung cancer is ready for prime time
FR Hirsch, PA Bunn - The lancet oncology, 2009 - thelancet.com
EGFR-directed therapies include the reversible specific tyrosine-kinase inhibitors (TKIs),
gefitinib and erlotinib, and the monoclonal antibody cetuximab. More recently, irreversible …
gefitinib and erlotinib, and the monoclonal antibody cetuximab. More recently, irreversible …
[DOC][DOC] LUX-Lung: determining the best EGFR inhibitor in NSCLC?
A Rossi, M Di Maio - The Lancet Oncology, 2015 - iris.unito.it
Since first reports, many publications showed data on incidence and characteristics of
epidermal growth factor receptor (EGFR) mutations in patients with non-small-cell lung …
epidermal growth factor receptor (EGFR) mutations in patients with non-small-cell lung …
Beyond first-line NSCLC therapy: chemotherapy or erlotinib?
L Paz-Ares - The Lancet Oncology, 2012 - thelancet.com
The EGFR signalling pathway is relevant in many tumour types and is a successful
exploitable target for anticancer treatment, including for non-small-cell lung cancer …
exploitable target for anticancer treatment, including for non-small-cell lung cancer …
[引用][C] Tyrosine kinase inhibitors as first-line treatment in NSCLC
M Maemondo - The Lancet Oncology, 2016 - thelancet.com
Several phase 3 studies comparing the first-generation EGFR tyrosine kinase inhibitors
gefitinib and erlotinib as first-line treatments have been done in non-small-cell lung cancer …
gefitinib and erlotinib as first-line treatments have been done in non-small-cell lung cancer …
Treatment choice in EGFR-mutant non-small-cell lung cancer
WM Brueckl - The Lancet Oncology, 2017 - thelancet.com
This trial adds evidence to the hypothesis that second-generation TKIs are more effective, at
least with respect to progression-free survival, than are first-generation TKIs. However …
least with respect to progression-free survival, than are first-generation TKIs. However …
Pharmacokinetics of gefitinib and erlotinib
D Levêque - The Lancet Oncology, 2011 - thelancet.com
In a Comment1 on the OPTIMAL trial, 2 Tetsuya Mitsudomi suggests that differences in
clinical activity between the oral kinase inhibitors erlotinib and gefitinib in EGFR mutation …
clinical activity between the oral kinase inhibitors erlotinib and gefitinib in EGFR mutation …
A new generation of EGFR tyrosine-kinase inhibitors in NSCLC.
FR Hirsch, PA Bunn Jr - The Lancet. Oncology, 2012 - europepmc.org
This is a comment on" Afatinib for patients with lung adenocarcinoma and epidermal growth
factor receptor mutations (LUX-Lung 2): a phase 2 trial." Lancet Oncol. 2012 May; 13 (5) …
factor receptor mutations (LUX-Lung 2): a phase 2 trial." Lancet Oncol. 2012 May; 13 (5) …
EGFR mutations in non-small-cell lung cancer
JJ Hung, WJ Jeng, WH Hsu, JS Liu, YC Wu - The Lancet Oncology, 2010 - thelancet.com
Reflection and Reaction www. thelancet. com/oncology Vol 11 May 2010 413 in specimens
taken during primary-tumour resection, and in those taken from the biopsy of recurrent …
taken during primary-tumour resection, and in those taken from the biopsy of recurrent …
Targeting MET in EGFR resistance in non-small-cell lung cancer—ready for daily practice?
S Schmid, M Früh, S Peters - The Lancet Oncology, 2020 - thelancet.com
The EGFR mutation was discovered as oncogenic driver in non-small-cell lung cancer
(NSCLC) more than 15 years ago. Unfortunately, resistance universally develops on EGFR …
(NSCLC) more than 15 years ago. Unfortunately, resistance universally develops on EGFR …