Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation
BG Wilson, KC Helming, X Wang, Y Kim… - … and cellular biology, 2014 - Am Soc Microbiol
Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex
are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of …
are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of …
Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer
PP Medina, M Sanchez-Cespedes - Epigenetics, 2008 - Taylor & Francis
The SWI/SNF complex is a chromatin-remodeling complex that uses the energy of ATP
hydrolysis to modify chromatin structure in order to regulate gene expression. The SWI/SNF …
hydrolysis to modify chromatin structure in order to regulate gene expression. The SWI/SNF …
High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer
JA Guerrero-Martínez, JC Reyes - Scientific reports, 2018 - nature.com
The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes
SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor …
SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor …
SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy
K Mardinian, JJ Adashek, GP Botta, S Kato… - Molecular cancer …, 2021 - AACR
The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers: insights from cDNA rescue and PFI-3 inhibitor studies
B Vangamudi, TA Paul, PK Shah, M Kost-Alimova… - Cancer research, 2015 - AACR
The SWI/SNF multisubunit complex modulates chromatin structure through the activity of two
mutually exclusive catalytic subunits, SMARCA2 and SMARCA4, which both contain a …
mutually exclusive catalytic subunits, SMARCA2 and SMARCA4, which both contain a …
The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting
Perturbations to mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin
remodeling complexes have been widely implicated as driving events in cancer. One such …
remodeling complexes have been widely implicated as driving events in cancer. One such …
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients
Genomic studies performed in cancer patients and tumor-derived cell lines have identified a
high frequency of alterations in components of the mammalian switch/sucrose non …
high frequency of alterations in components of the mammalian switch/sucrose non …
Genetic and epigenetic screening for gene alterations of the chromatin‐remodeling factor, SMARCA4/BRG1, in lung tumors
PP Medina, J Carretero, MF Fraga… - Genes …, 2004 - Wiley Online Library
The SMARCA4/BRG1 gene product is a component of the SWI‐SNF chromatin‐remodeling
complex and regulates gene expression by disrupting histone‐DNA contacts in an ATP …
complex and regulates gene expression by disrupting histone‐DNA contacts in an ATP …
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
C Kadoch, GR Crabtree - Science advances, 2015 - science.org
Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
GR Hoffman, R Rahal, F Buxton… - Proceedings of the …, 2014 - National Acad Sciences
Defects in epigenetic regulation play a fundamental role in the development of cancer, and
epigenetic regulators have recently emerged as promising therapeutic candidates. We …
epigenetic regulators have recently emerged as promising therapeutic candidates. We …