Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells

O Isacson, LM Bjorklund… - Annals of Neurology …, 2003 - Wiley Online Library
New therapeutic nonpharmacological methodology in Parkinson's disease (PD) involves
cell and synaptic renewal or replacement to restore function of neuronal systems, including …

Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease

O Lindvall, Z Kokaia - Trends in Pharmacological sciences, 2009 - cell.com
In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA)
neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic …

[HTML][HTML] Cell therapeutics in Parkinson's disease

O Lindvall, A Björklund - Neurotherapeutics, 2011 - Elsevier
The main pathology underlying motor symptoms in Parkinson's disease (PD) is a rather
selective degeneration of nigrostriatal dopamine (DA) neurons. Intrastriatal transplantation …

Cell implantation therapies for Parkinson's disease using neural stem, transgenic or xenogeneic donor cells

O Isacson, L Costantini, JM Schumacher… - Parkinsonism & related …, 2001 - Elsevier
A new therapeutic neurological and neurosurgical methodology involves cell implantation
into the living brain in order to replace intrinsic neuronal systems, that do not spontaneously …

[HTML][HTML] Recent advances in cell-based therapy for Parkinson disease

A Astradsson, O Cooper, A Vinuela, O Isacson - Neurosurgical Focus, 2008 - thejns.org
✓ In this review, the authors discuss recent advances in the field of cell therapy for Parkinson
disease (PD). They compare and contrast recent clinical trials using fetal dopaminergic …

Stem cells for cell therapy in Parkinson's disease

O Lindvall - Pharmacological research, 2003 - Elsevier
Clinical studies with intrastriatal transplants of human embryonic mesencephalic tissue have
provided proof-of-principle for the cell replacement strategy in Parkinson's disease (PD) …

Neural stem cells and transplantation studies in Parkinson's disease

R Pardal, J López-Barneo - Stem cell transplantation, 2012 - Springer
Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
primarily caused by the selective degeneration of specific neuronal populations, particularly …

Rewiring the brain with cell transplantation in Parkinson's disease

A Gaillard, M Jaber - Trends in neurosciences, 2011 - cell.com
Cell replacement therapy has been proposed as a means to replace lost dopaminergic
neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been …

Current advances in the treatment of Parkinson's disease with stem cells

KA Trzaska, P Rameshwar - Current Neurovascular Research, 2007 - ingentaconnect.com
Stem cell replacement has emerged as the novel therapeutic strategy for Parkinson's
disease (PD). Control of motor behavior is lost in PD due to the selective degeneration of …

Isolation and transplantation of dopaminergic neurons and neural stem cells

H Okano, T Yoshizaki, T Shimazaki… - Parkinsonism & Related …, 2002 - Elsevier
Although transplantation of mesencephalic tissue is considered a promising therapy for
Parkinson's disease (PD), its clinical use is still restricted to a very few cases. A major …