PURPOSE: Tubulointerstitial fibrosis is the final common pathway to end stage renal
disease. The pathophysiology of renal fibrosis involves fibroblast proliferation, macrophage …

Recent publications have questioned whether epithelial-to-mesenchymal transition of
tubular epithelial cells is an important contributor to renal fibrosis. Two recent publications …

Despite a lot of research efforts, the origin of renal fibroblasts is still matter of debate.
Epithelial-mesenchymal transition (EMT) of tubular epithelial cells could be at least one of …

Obstructive nephropathy is a major cause of renal failure, particularly in newborn babies and
children. After urinary tract obstruction, and under the influence of mechanical forces and …

Tubulointerstitial fibrosis invariably accompanies the course of chronic renal failure towards
end-stage renal disease. Tubular epithelial cells, the predominant cell type in the …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …

All types of progressive chronic kidney disease (CKD) inevitably induce renal fibrosis, the
hallmark of which is the activation and accumulation of a large number of matrix-producing …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Abstract Changes in the tubulointerstitial compartment play an important role in the
progression of chronic renal disease to endstage renal failure. These changes consist of …

Mature tubular epithelial cells in adult kidney can undergo epithelial-to-mesenchymal
transition (EMT), a phenotypic conversion that is fundamentally linked to the pathogenesis of …