Abstract Considerable evidence implicates cyclic 3′, 5′ adenosine monophosphate
(AMP) in the maintenance of meiotic arrest of mammalian oocytes. Since this laboratory …

The effect of adenylate cyclase stimulation via the components of the enzyme on nuclear
maturation in bovine cumulus-enclosed and zona-free oocytes was examined. The …

The diterpene forskolin, which was found to be a potent and reversible activator of adenylate
cyclase in intact tissues as well as in broken cell preparations, was employed to investigate …

Previous studies indicate that an increase in calcium in the oocyte-cumulus complex (OCC)
appears to be associated with induction of oocyte maturation. In contrast, we previously …

Recent work on the mouse is discussed. The results support the view that cAMP participates
in the maintenance of meiotic arrest, and that purines may help sustain meiosis-arresting …

This study was carried out to test the hypothesis that purine nucleotide‐generating pathways
are required for ligand‐stimulated oocyte maturation in meiotically arrested cumulus cell …

The influence of cyclic nucleotides on meiosis in isolated rat oocytes was studied. It is known
that dbcAMP inhibits the spontaneous maturation of isolated rat oocytes. However, the effect …

Forskolin, a reversible stimulator of the catalytic subunit of adenylate cyclase, has been used
to determine:(1) whether an increase in hamster cumulus cell cyclic adenosine …

In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal
stage and the oocytes contained within are arrested at the dictyate stage of meiotic …

The effects of estradiol (E2) and the anti‐E2 tamoxifen (tam) on forskolin (F)‐dependent
meiotic arrest in hamster oocytes were investigated. The hypotheses tested were that (1) the …