Autosomal dominantly inherited ataxias are a clinically and genetically heterogeneous
group of neurodegenerative disorders. The gene involved in one subtype, spinocerebellar …

The spinocerebellar ataxias are a group of debilitating neurodegenerative diseases for
which a clinical classification system has proved unreliable. We have recently isolated the …

Abstract Spinocerebellar ataxia 2 (SCA2) is caused by the expansion of an unstable CAG
repeat encoding a polyglutamine tract. One hundred and eighty four index patients with …

Infantile‐and juvenile‐onset spinal cerebellar ataxia (SCA) is associated with expansion of
130 to more than 200 CAG‐repeats in the SCA2 and SCA7 genes. Routine clinical assays …

The spinocerebellar ataxia type 2 (SCA2) is caused by a trinucleotide (CAG) expansion in
the coding region of the ataxin 2 gene on chromosome 12q. 89 families with autosomal …

The autosomal dominant spinocerebellar ataxias (ADSCAs) are a heterogeneous group of
late-onset neurodegenerative disorders with overlapping clinical features. Genetic linkage …

Spinocerebellar ataxia-2 (SCA2) is an autosomal dominant ataxia caused by an abnormal
CAG repeat expansion in a novel gene on chromosome 12q24. 1. The size of the mutant …

The dominant cerebellar ataxias (ADCAs) represent a clinically and genetically
heterogeneous group of disorders linked by progressive deterioration in balance and …

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, neurodegenerative
disorder characterized by the progressive loss of neurons from the cerebellum, brain stem …

Spinocerebellar ataxia 6 (SCA6) is an autosomal dominant spinocerebellar degeneration
caused by the expansion of the polymorphic CAG repeat in the human α1A voltage …