Autosomal dominant cerebellar ataxias are a heterogeneous group of neurodegenerative
disorders that generally present in adulthood. Spinocerebellar ataxia type 2 typically …

Abstract Spinocerebellar ataxia type 2 (SCA2) is a progressive autosomal dominantly
inherited cerebellar ataxia and is assigned to the CAG repeat or polyglutamine diseases …

Background Ten neurodegenerative disorders characterized by spinocerebellar ataxia
(SCA) are known to be caused by trinucleotide repeat (TNR) expansions. However, in some …

We investigated a family with a new type of autosomal dominant cerebellar ataxia (ADCA) in
which pure cerebellar ataxia is often accompanied with epilepsy. No CAG repeat …

The spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative
disease characterized by gait and limb ataxia. This disease is caused by the expansion of a …

Spinocerebellar ataxia 1 (SCA1) is caused by expansion of an unstable CAG triplet repeat
located on the short arm of chromosome 6. Precise mapping has shown a positional …

Molecular genetics has had a major impact on neurology. The genes for many
neurodevelopmental and neurodegenerative disorders have been identified, and molecular …

Two forms of the neurodegenerative disorder spinocerebellar ataxia are known to be
caused by the expansion of a CAG (polyglutamine) trinucleotide repeat. By screening cDNA …

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of late-onset,
neurodegenerative disorders for which 10 loci have been mapped (SCA1, SCA2, SCA4 …

The spinocerebellar ataxia 3 locus (SCA3) for type I autosomal dominant cerebellar ataxia
(ADCA type I), a clinically and genetically heterogeneous group of neuro-degenerative …