Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

J Jia, W Le - Neuroscience bulletin, 2015 - Springer
Major depressive disorder (MDD) is a complicated multifactorial induced disease,
characterized by depressed mood, anhedonia, fatigue, and altered cognitive function …

[HTML][HTML] Targeting autophagy to counteract neuroinflammation: a novel antidepressant strategy

H Gan, Q Ma, W Hao, N Yang, ZS Chen, L Deng… - Pharmacological …, 2024 - Elsevier
Depression is a common disease that affects physical and mental health and imposes a
considerable burden on afflicted individuals and their families worldwide. Depression is …

Is there a role of autophagy in depression and antidepressant action?

NC Gassen, T Rein - Frontiers in Psychiatry, 2019 - frontiersin.org
Autophagy has been recognized as evolutionary conserved intracellular pathway that
ensures energy, organelle, and protein homeostasis through lysosomal degradation of …

[HTML][HTML] In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders

DI Sánchez-Vidaña, J Li, S Abokyi… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …

Is autophagy involved in the diverse effects of antidepressants?

T Rein - Cells, 2019 - mdpi.com
Autophagy has received increased attention as a conserved process governing cellular
energy and protein homeostasis that is thus relevant in a range of physiological and …

Stress and signaling pathways regulating autophagy: from behavioral models to psychiatric disorders

BC Pierone, CA Pereira, ML Garcez, MP Kaster - Experimental Neurology, 2020 - Elsevier
Autophagy is a process of degradation and recycling of cytoplasmatic components by the
lysosomes. In the central nervous system (CNS), autophagy is involved in cell surveillance …

Exploring the role of autophagy dysfunction in neurodegenerative disorders

T Rana, T Behl, A Sehgal, V Mehta, S Singh… - Molecular …, 2021 - Springer
Autophagy is a catabolic pathway by which misfolded proteins or damaged organelles are
engulfed by autophagosomes and then transported to lysosomes for degradation. Recently …

[HTML][HTML] Pharmacological modulation of autophagy for Alzheimer's disease therapy: opportunities and obstacles

Z Deng, Y Dong, X Zhou, JH Lu, Z Yue - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Alzheimer's disease (AD) is a prevalent and deleterious neurodegenerative disorder
characterized by an irreversible and progressive impairment of cognitive abilities as well as …

Autophagy modulation for Alzheimer's disease therapy

XC Zhu, JT Yu, T Jiang, L Tan - Molecular neurobiology, 2013 - Springer
Autophagy is an essential and conserved lysosomal degradation pathway that controls the
quality of cytoplasm by eliminating the intracellular aggregated proteins and damaged …

Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …