Objective Alpha smooth muscle actin (α-SMA) expression in stroma is linked to the presence
of cancer-associated fibroblasts and is known to correlate with worse outcomes in various …

Alpha‐smooth muscle actin (α‐SMA) expression in the stroma is linked to the presence of
cancer‐associated fibroblasts and is known to correlate with worse outcomes in various …

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers, with a
5-year survival rate of only 13%. PDAC develops from precursor lesions, most commonly …

In a single-cell RNA sequencing (scRNA-seq) study published in Cell, a team of researchers
have identified cancer cell phenotypes that can be used to classify tumour glands from …

Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous and lethal. Long
noncoding RNAs (lncRNAs) are an important class of genes regulating tumorigenesis and …

Aims: Using Single-cell RNA sequencing (scRNA-seq), we explored the spatiotemporal
heterogeneity of pancreatic neuroendocrine tumors (pNETs) and the underlying mechanism …

Multiple endocrine neoplasia 1 (MEN1) syndrome, a disease arising from a genetic
predisposition to tumor development caused by MEN1 loss-of-function mutations, is …

Alterations in alternative splicing are emerging as a novel hallmark in cancer biology,
offering new insights. However, integrative analyses of splicing are still scarce, particularly in …

INTRODUCTION Pancreatic ductal adenocarcinoma (PDAC) arises from either pancreatic
intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasm (IPMN) …

Background/objectives An abundant stromal reaction is a hallmark of pancreatic ductal
adenocarcinoma (PDAC) and chronic pancreatitis (CP). The cells mainly responsible for the …