Background: Previous investigations in pancreatic cancer suggest a prognostic role for α-
smooth muscle actin (α-SMA) expression and stromal density in the peritumoural stroma …

To understand the architecture of a tissue it is necessary to know both the cell populations
and their physical relationships to one another. Single-cell RNA-Seq (scRNA-Seq) has …

During the course of pancreatic neuroendocrine tumors (NETs), they generally become
more heterogeneous with individual cells exhibiting distinct molecular fingerprints. This …

The tumor microenvironment (TME) presents a complex ecosystem comprising a diversity of
immune and stromal cell populations that influence tumor progression, drug delivery and …

Objective Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with
limited therapeutic options. Genome and transcriptome analyses have identified signalling …

To understand tissue architecture, it is necessary to understand both which cell types are
present and the physical relationships among them. Single-cell RNA-Seq (scRNA-Seq) has …

Pancreatic cancer is characterized by an expansive, desmoplastic stroma that responds to
neoplastic signals from the malignant epithelium while also instigating a cacophony of …

Spatial transcriptomics (ST) is a powerful approach for cancers molecular and cellular
characterization. Pancreatic intraepithelial neoplasia (PanIN) is a pancreatic ductal …

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous
malignancies that arise from complex cellular interactions within the tissue …

Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell
populations in a tissue, but characterizing their spatial organization remains challenging. We …